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In the course of the early Thirties in Chicago, the transcontinental practice, Flying Pussyfoot, is beginning its legendary journey that may depart a path of blood everywhere in the nation. On the identical time in New York, the formidable scientist Szilard and his unwilling aide Ennis are searching for lacking bottles of the immortality elixir. As well as, a struggle between the mafia teams is getting worse. On board the Advena Avis, in 1711, alchemists are about to be taught the value of immortality.
Based mostly on the award-winning light novels of the identical identify, Baccano! follows a number of occasions that originally appear unrelated, each in time and place, however are a part of a a lot greater story—one in every of alchemy, survival, and immortality. Merging these occasions collectively are the kindhearted would-be thieves, Isaac and Miria, connecting numerous folks, all of them with their very own hidden ambitions and agendas, and creating lifelong bonds and penalties for everybody concerned.